The purpose of the present study is to investigate the neuropharmacological profile of Portulaca olaracea, by different methods like Elevated plus maze, Foot shock induced aggression, Morris water maze test. Elevated plus maze results indicates that the time spent in open arm were significantly increased in dose dependant manner in AEPO (1000mg/kg & 2000mg/kg) when compared to control group. The ratio of number of entries in open arm /total entries was reduced with increase in the dose. The results are comparable with that of standard. The ratio of number of entries in open arm / total entries vs drug treatment was observed in foot shock induced aggression. The AEPO (1000mg/kg & 2000mg/kg) showed a decrease in the number of fighting bouts with increase in the dose when compared to control supports of the anxiolytic activity was observed. In Morris water maze test the AEPO (1000mg/kg & 2000mg/kg) showed a decrease in the number of fighting bouts with increase in the dose when compared to control supports of the anxiolytic activity. The Elevated plus Maze Test is based on a premise where the exposure to an EPM evoked an approach –avoidance conflict that was considerably stronger than that evoked by the exposure to an enclosed arm .To further assess anxiolytic effect we used Open field test, Foot shock induced aggression. (AEPO- aqueous extract of Portulaca olaracea)
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